I block twitter accounts. A lot.
I can't recall I've blocked somebody over a comment or an interaction.
But I block the advertiser of every advertisement.
I block fake posters and likers of my content.
I probably had 15,000 blocked accounts. I follow like 2,000.
But with X going Premium and offering no ads, I thought it'd be a good time to forgive and forget (or soft delete as it were), and go back to 0 blocked users and see what happens.
Here's a script I ran to click "unblock" for every account I was blocking.
https://gist.github.com/afomi/7dd3544d2497a9a3c74846291b864036